Clinical case of brain tumors’ combination with different histological structure 

Elizaveta A. Semenovykh, Resident of the sub-department of pathological anatomy, Izhevsk State Medical Academy (281 Kommunarov street, Izhevsk, Russia), odin_kot@list.ru
Sergey A. Sukhanov, Head of the department of pathology, Oncology Dispensary of Udmurt Republic (3 Truda street, Izhevsk, Russia), pao@onco18.ru
Egor A. Lozhkin, Pathologist, Oncology Dispensary of Udmurt Republic (3 Truda street, Izhevsk, Russia), gogegor@yandex.ru
Nikolay A. Kir'yanov, Doctor of medical sciences, professor, head of the sub-department of pathological anatomy, Izhevsk State Medical Academy (281 Kommunarov street, Izhevsk, Russia), kirnik@list.ru

Background. Simultaneous development of two or more primary central nervous system tumors from different cell types is rare. The literature reports about combination of glial tumors of varying degrees of maturity with meningiomas, neurinomas and pituitary tumors. Describe a clinical case of a combination glioblastoma and brain neuroma in one patient. Material and methods. Patient L., 72 years old, hospitalized in the neurological department by the emergency medical team. The patient had neurological and psychiatric problems. During her hospitalization, she conducted general clinical, laboratory and instrumental methods of research. The article describe in details the history of the disease, clinical manifestations, results of computer tomography and pathomorphological studies. Results. Examination of the patient led to the detection of a tumor in the left temporooccipital region. However, the serious condition of the patient did not allow for operative treatment. Developed brain edema led the patient to death. In autopsy, two tumors were found - a glioblastoma of the occipital lobe of the left hemisphere and a neuroma of the left cerebellar corner. Histogenesis of tumors is determined by the use of both histological and immunohistochemical methods. Conclusions. These data show the need to develop methods of timely diagnosis of multiple intracranial tumors.

 multiple tumors, brain, Clinical case, histological structure

Semenovykh E.A., Sukhanov S.A., Lozhkin E.A., Kir'yanov N.A. Clinical case of brain tumors’ combination with different histological structure. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki = University proceedings. Volga region. Medical sciences. 2023;(1):109–116. (In Russ.). doi:10.21685/2072-3032-2023-1-10